I have this frequent argument with myself.
Meek Kate: My story is too out there. It'll make readers uncomfortable. They'll wonder what's wrong with me!
Bold Kate: Every novel I've ever loved was out there (at least for its time). Every one was the result of an author's courage. Mine probably isn't out there enough! Man up, you lily-livered whine lover!
Obviously Meek Kate loses every argument, but she continues to worry that risk-taking in novels is a little like risk-taking in fashion. It's universally spoken of as a Good Thing, but if you go too far, it's unlikely anyone whose opinion matters will ever tell you. As far as I know, there is no form rejection for "this is batshit crazy and who the fuck do you think you are?" No, you'll get a polite "not for us," which could mean anything and is a waste of analysis.
Of course, there is an obvious explanation for the lack of "batshit crazy" forms. Of all the reasons agents and editors reject fiction, too audacious is probably at the bottom of the list.
The lesson to Meek Kate is to stop flattering yourself with this nonsense and spend your energy worrying about execution.